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Hope for Alzheimer’s Cure?

By Shlomo Maital


Prof. Dan Michaelson

My family physician recently told me that about half of the elderly aged 85 and over have Alzheimer’s.   That should make Alzheimer’s a top priority for research money. But it is far from it.

Today’s Hebrew daily Maariv reports on a major breakthrough. Tel Aviv U. Prof. Dan Michaelson, along with his doctoral student Anat Bam-Cogan, have found a drug that can combat Alzheimer’s in mice. Here is the story:

     There are apparently quite a few ‘varieties’ of Alzheimer’s, just as there are types of cancer. Michaelson notes that 413 clinical trials, that tested 244 anti-Alzheimer’s drugs over the past 13 years, all failed!   Why? Maybe because Alzheimer’s is many diseases, not just one, he reasoned.

     Michaelson decided to tackle one type, related to specific genes ApoE3 and ApoE4.   Lab mice that have this defective gene develop Alzheimer’s. Michaelson tested the theory that the key protein that the defective ApoE4 gene makes fails to attach itself to fat cells properly, leading to the Alzheimer “plaque”. He contacted a biotech company Artery, and got from it a protein (peptide) that helps ‘stick’ fat cells to the protein. And it worked.   The peptide fixed the Alzheimer’s mice’s   cognitive problems and repaired the plaque in their brains.

     This is still a very long way from a drug that will help, or even cure, Alzheimer’s in humans. But it is a big step in the right direction.   We await more news from Dr. Michaelson, with hope.

Teach Preschoolers to Write:  The Evidence

By Shlomo  Maital


    “Preschoolers should be encouraged to write at a young age — even before they make their first step into a classroom.”  This is the finding of a new study, published in Early Childhood Research Quarterly, by Tel Aviv Univ. Professor Dorit Aram and her colleagues.  According to a Tel Aviv U. Press Release:

       “Parents in the U.S. are obsessed with teaching their kids the ABCs,” said Prof. Aram. “Probably because English is an ‘opaque’ language. Words do not sound the way they are spelled, unlike ‘transparent’ Spanish or Italian. Parents are using letters as their main resource of teaching early literacy, but what they should be doing is ‘scaffolding’ their children’s writing, helping their children relate sounds to letters on the page even though the letters are not transparent.”

      According to the Press Release,    Prof. Aram spent the last 15 years studying adult support of young children’s writing.  A major component of this support is a method,  in which a caregiver (i.e. parent)  is actively involved in helping a child break down a word into segments to connect sounds to corresponding letters. For example, parents using a high level will assist their children by asking them to “sound out” a word as they put it to paper. This contradicts the traditional model of telling children precisely which letters to print on a page, spelling it out for them as they go.

“Early writing is an important but understudied skill set,” said Prof. Aram. “Adults tend to view writing as associated with school, as ‘torture.’ My experience in the field indicates that it’s quite the opposite — children are very interested in written language. Writing, unlike reading, is a real activity. Children watch their parents writing and typing, and they want to imitate them. It is my goal to assist adults in helping their children enter the world of writing by showing them all the lovely things they can communicate through writing, whether it’s ‘mommy, I love you’ or even just ‘I want chocolate.'”

 In the study, 135 preschool children (72 girls and 63 boys) and their parents (primarily mothers) in an ethnically-diverse, middle-income US community were observed writing a semi-structured invitation for a birthday party. The researchers analyzed the degree of parental support and assessed the children’s phonological awareness, alphabet knowledge, word decoding, vocabulary, and fine motor skills. Overall   support was most positively linked to children’s decoding and fine motor skills.

    Prof. Aram and her counterparts found that “scaffolding,” or parental support, was most useful in developing early literacy skills. “The thing is to encourage children to write, but to remember that in writing, there is a right and a wrong,” said Prof. Aram. “We have found that scaffolding is a particularly beneficial activity, because the parent guides the child. And, if that parent guides the child and also demands precision in a sensitive and thoughtful way — i.e. ‘what did you mean to write here? Let me help you’ — this definitely develops the child’s literary skill set.

    So, bottom line:   Sit down with your very young pre-schoolers as parents or grandparents.  Work with them on writing.  “Sound it out” is the message…not  “Here is how you spell a word precisely”.  It makes sense to me. 


Blog entries written by Prof. Shlomo Maital

Shlomo Maital